Bills vs. Panthers 2025 Prediction, Odds, Picks
Updated on October 26, 2025, at 12:43 p.m. ET
The Carolina Panthers (4-3) are looking to extend their winning streak to four games as they face off against the Buffalo Bills (4-2) no brand branches quezon city. Despite the Panthers’ recent success, the Bills are favored to win by a margin of at least a touchdown, currently set at -7.5. The total points for the matchup is over/under 47.5 points.
Bills vs. Panthers Odds & Betting Lines
Updated as of October 26, 2025, at 11:33 a.m. ET:
- Favorite: Bills
- Spread: -7.5
- Odds (Bills): -108
- Underdog: Panthers
- Spread Odds: +7.5 -123
- Total Points: 47.5
- Over Odds: -112
- Under Odds: -108
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Bills vs. 777pub.com apk Panthers Prediction & Pick
Pick ATS: Panthers (+7.5)
Pick OU: Under (47.5)
Prediction: Panthers 24 – Bills 22
How to Watch Buffalo vs. Carolina
Game date: Sunday, October 26, 2025
Time: 1 p.m. ET
Venue: Bank of America Stadium
Location: Charlotte, North Carolina
TV: Watch on FOX
Streaming: FOXSports.com, FOX Sports App, and FOX One (Try free for 7 days)
Bills vs. Panthers Recent Matchups
The last two encounters between Buffalo and Carolina have been closely contested, with each team winning one game. In those matchups, Carolina has been outscored by a total of 11 points against Buffalo.
Buffalo Betting Info
In 2025, Buffalo has covered the spread two times. This season, the Bills have struggled when favored by at least 7.5 points, holding an 0-3 record against the spread. Games involving Buffalo have surpassed the point total 50% of the time, with three overs in six contests. When listed as moneyline favorites, the Bills have been successful 60% of the time (3-2). Their implied win probability based on the moneyline stands at 79.8%.
Bills Stats
- Pass yards: 227.3 (total: 1,364) – Rank: 11
- Rush yards: 151.0 (total: 906) – Rank: 1
- Points scored: 27.8 (total: 167) – Rank: 12
- Pass yards against: 167.2 (total: 1,003) – Rank: 2
- Rush yards against: 156.3 (total: 938) – Rank: 31
- Points allowed: 22.8 (total: 137) – Rank: 17
Buffalo’s Key Players
Offense
Josh Allen has thrown for 1,397 yards, scoring 11 touchdowns (10th in the NFL) and four interceptions this season. He boasts a 68.5% completion rate, averaging 232.8 yards per game at 7.8 yards per attempt. okebet 168 Additionally, he has rushed for 254 yards (42.3 per game) and three touchdowns.
James Cook averages 5 yards per carry (11th in the NFL) with 89.5 rushing yards per game, contributing 537 total rushing yards (fourth in the NFL) and five rushing touchdowns this season. He has also made 12 receptions for 89 receiving yards without a touchdown, averaging 14.8 receiving yards and two catches per game.
Dalton Kincaid has caught three touchdown passes this season, with 20 receptions for 287 yards on 24 targets, averaging four receptions and 57.4 yards per game. Khalil Shakir has amassed 268 receiving yards and two touchdowns on 25 catches from 34 targets, averaging 4.2 receptions and 44.7 yards per game.
Defense
Defensively, Terrel Bernard has recorded 30 tackles, three tackles for loss (TFL), and one interception in 2025. Cole Bishop leads the Bills in sacks with two, alongside his two TFL and 27 tackles. Joey Bosa has contributed with 14 tackles, two TFL, and two sacks this season. Shaq Thompson has also made his mark with 23 tackles, three TFL, and one sack this year.
Carolina Betting Info
The Panthers have achieved a 5-2-0 record against the spread this year, with four games surpassing the point total set by bookmakers. Carolina has been regarded as the underdog seven times this season, managing to clinch four victories. The moneyline odds suggest a 24.4% chance of winning for the Panthers.
Panthers Stats
- Pass yards: 186.6 (total: 1,306) – Rank: 26
- Rush yards: 140.1 (total: 981) – Rank: 3
- Points scored: 20.7 (total: 145) – Rank: 21
- Pass yards against: 203.1 (total: 1,422) – Rank: 10
- Rush yards against: 92.6 (total: 648) – Rank: 8
- Points allowed: 21.7 (total: 152) – Rank: 13
Carolina’s Key Players
Offense
Bryce Young has passed for 1,288 yards this season, throwing 11 touchdowns (10th in the NFL) and five interceptions. He has completed 61.6% of his passes, with an average of 184 yards per game and 5. national id track and trace8 yards per attempt. On the ground, he has added a rushing touchdown and 69 rushing yards (fourth on the Panthers).
Rico Dowdle leads the Panthers with 551 rushing yards (third in the NFL) and has scored two rushing touchdowns, averaging 78.7 yards per game and 5.6 per carry (first in the NFL). Dowdle has also brought in 121 receiving yards on 13 catches (1.9 per game) and has one touchdown reception.
Tetairoa McMillan has made 30 catches (4.3 receptions per game on 7.6 targets per game) for 413 yards and two touchdowns throughout this season. Chuba Hubbard has yet to score on the ground but has gained 248 total rushing yards at 3 daily promo codes.7 yards per carry and 49.6 per game. He also has caught 15 passes for 118 yards (fifth on the Panthers), with two receiving touchdowns to his name.
Defense
Thus far in 2025, Tre’von Moehrig leads the Panthers with 46 tackles, six TFL, and one sack over seven games. Derrick Brown has notched three sacks along with two TFL and 26 tackles throughout the season. Christian Rozeboom has recorded 50 tackles and one TFL during this campaign. Mike Jackson Sr. has also added two TFL, 28 tackles, and one interception over the same span.
FOX Sports put together this article using technology provided by Data Skrive and data sourced from Sportradar. Are you excited to see how this matchup turns out?